Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic oligopeptide derived from Angiotensin IV that acts as a potent hepatocyte growth factor (HGF) mimetic. It binds to the c-Met receptor with approximately 10 million times greater potency than brain-derived neurotrophic factor (BDNF) in promoting neuronal synaptogenesis. Dihexa has demonstrated remarkable cognitive enhancement properties in preclinical models of dementia and neurodegenerative disease. We provide research-grade Dihexa in lyophilized form for institutional neuroscience research.
| Sequence | N-hexanoic-Tyr-Ile-(6) aminohexanoic amide |
| Molecular Formula | C24H39N3O4 |
| Molecular Weight | 433.59 g/mol |
| Purity | ≥98% (HPLC) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated, protected from light |
| CAS | 1401708-83-5 |
McCoy AT et al. (2013) published in The Journal of Pharmacology and Experimental Therapeutics the landmark finding that Dihexa augments HGF/c-Met signaling to promote synaptogenesis with potency 7 orders of magnitude greater than BDNF.
Benoist CC et al. (2014) demonstrated in Frontiers in Pharmacology that Dihexa crosses the blood-brain barrier and rescues cognitive deficits in a scopolamine-induced amnesia model.
Research published in Neurobiology of Learning and Memory (2015) confirmed Dihexa's ability to enhance spinogenesis and dendritic branching through HGF-dependent mechanisms in hippocampal neurons.
Dihexa is a synthetic oligopeptide derived from Angiotensin IV that acts as an ultra-potent hepatocyte growth factor (HGF) mimetic. It promotes synaptogenesis through c-Met receptor activation with approximately 10 million times greater potency than BDNF.
We supply Dihexa at ≥98% (HPLC) purity with comprehensive Certificate of Analysis including mass spectrometry confirmation, HPLC chromatogram, and residual solvent analysis.
Dihexa is an experimental research compound not approved by any regulatory agency for human use. It is available strictly for in vitro and preclinical research purposes at licensed institutions.
MOQ for Dihexa depends on the quantity required. Contact our sales team for specific pricing and availability.
Store Dihexa at -20°C in lyophilized form, protected from light and moisture. After reconstitution in DMSO, aliquot and store at -80°C for long-term stability.
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