MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome — making it one of the few known mitochondrial-derived peptides (MDPs) with systemic signaling functions. Research published in Cell Metabolism demonstrates that MOTS-c regulates metabolic homeostasis by activating AMPK, enhancing glucose uptake, improving insulin sensitivity, and mimicking some effects of exercise at the cellular level. It has been dubbed the 'exercise peptide' due to its ability to improve physical performance and metabolic health in animal models. MOTS-c is at the frontier of longevity and metabolic research, with rapidly growing academic and commercial interest.
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.58 g/mol |
| Purity | ≥95% (HPLC) |
| Form | Lyophilized powder |
| Storage | -20°C |
| CAS | 1627580-64-6 |
Mitochondrial-derived peptide regulating metabolic homeostasis, insulin sensitivity, and exercise physiology research.
We supply MOTS-c at ≥95% (HPLC) purity. Higher purity grades are available for pharmaceutical applications upon request.
Minimum order quantities for wholesale MOTS-c depend on the quantity and purity grade required. Contact our sales team for specific pricing and MOQ information.
MOTS-c should be stored at -20°C in a desiccated environment. Proper cold-chain shipping is maintained for all deliveries.
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