PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist peptide developed from Melanotan II. It acts on the central nervous system through MC3R and MC4R receptors to modulate sexual arousal pathways. PT-141 was FDA-approved in 2019 under the brand name Vyleesi for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. As a B2B supplier, we provide pharmaceutical-grade PT-141 in lyophilized powder form with verified purity exceeding 99% by HPLC analysis.
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.18 g/mol |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated |
| CAS | 189691-06-3 |
Kingsberg SA et al. (2019) published in Obstetrics & Gynecology the RECONNECT phase 3 trial results demonstrating Bremelanotide's significant efficacy in treating HSDD with favorable safety profile.
Research by Clayton AH et al. (2016) in The Journal of Sexual Medicine confirmed that PT-141 acts through melanocortin-4 receptor activation, providing a novel central mechanism for sexual desire enhancement.
A comprehensive review in Expert Opinion on Pharmacotherapy (2020) highlighted Bremelanotide as the first melanocortin agonist approved for sexual dysfunction, representing a new therapeutic class.
PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist. It acts on MC3R and MC4R receptors in the central nervous system to modulate sexual arousal pathways. It was FDA-approved in 2019 as Vyleesi.
We supply PT-141 at ≥99% (HPLC) purity with comprehensive Certificate of Analysis including mass spectrometry, amino acid analysis, and endotoxin testing per ICH guidelines.
While both are melanocortin agonists, PT-141 was specifically engineered from Melanotan II to selectively target sexual function pathways via MC3R/MC4R receptors, with significantly reduced melanogenic (tanning) activity compared to Melanotan II.
MOQ for wholesale PT-141 depends on the quantity and grade required. Contact our sales team for specific pricing information.
PT-141 should be stored at -20°C in lyophilized form, protected from light and moisture. After reconstitution, store at 2-8°C and use within 14 days.
Melanocortin agonist peptide for melanogenesis stimulation and skin pigmentation...
View Details Research PeptidesPeptide regulating the hypothalamic-pituitary-gonadal axis for LH and FSH stimulation...
View Details Pharmaceutical PeptidesPentadecapeptide for systemic and localized tissue healing...
View Details Research PeptidesNootropic and anxiolytic peptide with immunomodulatory properties...
View Details