5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme increasingly recognized as a key regulator of metabolism and energy homeostasis. By inhibiting NNMT, 5-Amino-1MQ increases NAD+ and SAM concentrations in cells, promoting energy expenditure and reducing fat accumulation.
| Sequence / Structure | C10H11N2+ (non-peptide small molecule) |
| Molecular Weight | 173.21 g/mol |
| Purity | >=99% |
| Appearance | White lyophilized powder |
| Storage | Store at room temperature, protect from light |
| Solubility | Soluble in water and DMSO |
Neelakantan H, Vance V, Wetzel MD, et al. (2018) — Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. DOI: 10.1016/j.bcp.2018.07.007
Kraus D, Yang Q, Kong D, et al. (2014) — Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. DOI: 10.1038/nature13198
Pissios P. (2017) — Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. DOI: 10.1016/j.tem.2017.02.004
5-Amino-1MQ is a small molecule inhibitor of NNMT, an enzyme that regulates cellular energy metabolism and fat storage.
Inhibiting NNMT increases intracellular NAD+ and SAM levels, activating energy expenditure pathways and reducing fat accumulation in adipocytes.
Our wholesale 5-Amino-1MQ is >=99% pure with comprehensive analytical documentation.
It is studied in obesity, metabolic syndrome, fat cell biology, NAD+ metabolism, and energy homeostasis research.
Store at room temperature, protected from moisture and light.
Yes, we provide competitive wholesale pricing with volume discounts.
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