MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome  making it one of the few known mitochondrial-derived peptides (MDPs) with systemic signaling functions. Research published in Cell Metabolism demonstrates that MOTS-c regulates metabolic homeostasis by activating AMPK, enhancing glucose uptake, improving insulin sensitivity, and mimicking some effects of exercise at the cellular level. It has been dubbed the 'exercise peptide' due to its ability to improve physical performance and metabolic health in animal models. MOTS-c is at the frontier of longevity and metabolic research, with rapidly growing academic and commercial interest.
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.58 g/mol |
| Purity | ≥95% (HPLC) |
| Form | Lyophilized powder |
| Storage | -20°C |
| CAS | 1627580-64-6 |
According to comprehensive reviews in the Journal of Peptide Science, synthetic therapeutic peptides represent one of the fastest-growing segments of the pharmaceutical industry.
Research published in Trends in Pharmacological Sciences (2023) highlights the importance of peptide purity exceeding 99% for reproducible preclinical research outcomes.
Mitochondrial-derived peptide regulating metabolic homeostasis, insulin sensitivity, and exercise physiology research.
We supply MOTS-c at ≥95% (HPLC) purity. Higher purity grades are available for pharmaceutical applications upon request.
Minimum order quantities for wholesale MOTS-c depend on the quantity and purity grade required. Contact our sales team for specific pricing and MOQ information.
MOTS-c should be stored at -20°C in a desiccated environment. Proper cold-chain shipping is maintained for all deliveries.
Every batch includes a comprehensive Certificate of Analysis with HPLC purity data (≥99%), mass spectrometry confirmation, amino acid analysis, endotoxin testing (<0.5 EU/mg), and residual solvent analysis per ICH Q3C guidelines.
In-stock peptides are dispatched within 48 hours of order confirmation. International delivery takes 5–7 business days via temperature-controlled shipping. Express 2–3 day options available. Our on-time delivery rate is 99.2%.
Yes. Dr. Peptides provides Drug Master File (DMF) documentation, Certificates of Origin, MSDS/SDS in multiple languages, and stability data packages compliant with ICH guidelines for regulatory submissions.
Dr. Peptides offers a 100% money-back quality guarantee. If any product fails to meet the purity specifications stated on its Certificate of Analysis, we provide a full replacement or refund within 48 hours of claim receipt.
All shipments use pharmaceutical-grade insulated packaging with qualified gel packs maintaining 2–8°C for up to 96 hours. Each package includes a temperature data logger for verification upon receipt, per WHO guidelines for temperature-sensitive pharmaceuticals.
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