ACE-031 is a soluble form of the activin receptor type IIB (ActRIIB) fused to a human IgG1 Fc domain. It acts as a ligand trap, binding and neutralizing myostatin, activin, GDF-11, and other TGF-beta superfamily members that negatively regulate muscle mass. Research demonstrates significant muscle mass increases in preclinical and clinical studies.
| Sequence / Structure | ActRIIB extracellular domain fused to IgG1 Fc |
| Molecular Weight | ~90 kDa |
| Purity | >=95% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Attie KM, Borgstein NG, Yang Y, et al. (2013) — A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. DOI: 10.1002/mus.23539
Campbell C, McMillan HJ, Mah JK, et al. (2017) — Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy. Muscle Nerve. DOI: 10.1002/mus.25268
Cadena SM, Tomkinson KN, Monnell TE, et al. (2010) — Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type. J Appl Physiol. DOI: 10.1152/japplphysiol.00866.2009
ACE-031 is a soluble ActRIIB-Fc fusion protein that acts as a decoy receptor to trap myostatin and related TGF-beta superfamily ligands.
By binding myostatin, activin, and GDF-11, ACE-031 removes multiple negative regulators of muscle growth simultaneously, producing robust anabolic effects.
Our wholesale ACE-031 is >=95% pure with comprehensive quality documentation.
ACE-031 is studied in muscular dystrophy, sarcopenia, cachexia, bone metabolism, and TGF-beta superfamily signaling.
Store at -20C to -80C. Avoid repeated freeze-thaw cycles.
Yes, we offer competitive bulk pricing. Contact our sales team for details.
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