Adipotide (also known as FTPP or Prohibitin-TP01) is an experimental peptidomimetic that selectively targets blood vessels supplying white adipose tissue, inducing apoptosis in endothelial cells and causing rapid fat loss. Originally developed at MD Anderson Cancer Center, Adipotide works through a dual-domain structure: a targeting sequence that homes to adipose vasculature and a pro-apoptotic peptide that destroys the targeted cells. While demonstrating dramatic fat reduction in primate studies, clinical development was paused due to renal side effects, making it a compound of significant research interest in obesity and metabolic science.
| Sequence / Structure | CKGGRAKDC-GG-D(KLAKLAK)2 |
| Molecular Weight | ~2,800 g/mol |
| Purity | ≥98% |
| Appearance | White to off-white lyophilized powder |
| Storage | Store at -20°C, protect from light and moisture |
| Solubility | Soluble in sterile water or PBS |
Kolonin MG, Saha PK, Chan L, et al. (2004) — Reversal of obesity by targeted ablation of adipose tissue. Nat Med. DOI: 10.1038/nm1048
Barnhart KF, Christianson DR, Hanley PW, et al. (2011) — A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. DOI: 10.1126/scitranslmed.3002621
Adipotide is an experimental peptidomimetic compound that selectively targets and destroys blood vessels feeding white adipose tissue, leading to fat cell death and significant weight reduction in animal models.
Our wholesale Adipotide is manufactured to ≥98% purity with full HPLC certificates of analysis provided.
Adipotide is used in research on adipose tissue biology, vascular targeting strategies, obesity mechanisms, and targeted apoptosis pathways.
Store lyophilized Adipotide at -20°C, protected from light and moisture. After reconstitution, use within 14 days when stored at 2-8°C.
Contact our sales team for MOQ details and volume-based pricing for wholesale Adipotide.
No. Adipotide is an experimental research compound only. Clinical development was paused due to renal side effects observed in primate studies.
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