AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside, also known as Acadesine) is a cell-permeable nucleoside analog that activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. Upon cellular uptake, AICAR is phosphorylated to ZMP, which mimics AMP and allosterically activates AMPK. This activation triggers downstream metabolic effects including enhanced fatty acid oxidation, glucose uptake, and mitochondrial biogenesis — effects similar to those produced by exercise. AICAR has been extensively studied in metabolic research, diabetes, cardiovascular protection, and as an 'exercise mimetic' compound.
| Sequence / Structure | Non-peptide nucleoside analog (small molecule) |
| Molecular Weight | 258.23 g/mol |
| Purity | ≥99% |
| Appearance | White crystalline powder |
| Storage | Store at -20°C, protect from moisture and light |
| Solubility | Soluble in DMSO and water |
Narkar VA, Downes M, Yu RT, et al. (2008) — AMPK and PPARdelta agonists are exercise mimetics. Cell. DOI: 10.1016/j.cell.2008.06.051
Merrill GF, Kurth EJ, Hardie DG, et al. (1997) — AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol. DOI: 10.1152/ajpendo.1997.273.6.E1107
AICAR (Acadesine) is a nucleoside analog that activates AMP-activated protein kinase (AMPK), producing metabolic effects similar to physical exercise, including enhanced fat oxidation and glucose uptake.
Our wholesale AICAR is manufactured to ≥99% purity, verified by HPLC with full certificates of analysis.
AICAR is used in research on AMPK signaling, metabolic syndrome, exercise physiology, diabetes, and cardiovascular protection.
Store at -20°C protected from moisture and light. Stable for 2+ years under proper storage conditions.
Contact our sales team for bulk pricing and MOQ details on AICAR.
No, AICAR is a nucleoside analog (small molecule), but it is commonly sold alongside peptides due to its use in similar metabolic and performance research contexts.
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