Amlexanox is a small molecule inhibitor of the non-canonical IκB kinases IKKε and TBK1, originally developed as an anti-allergic and anti-inflammatory agent for treating aphthous ulcers and asthma. Recent research has revealed its potential as a metabolic modulator — inhibition of IKKε/TBK1 reverses diet-induced obesity, insulin resistance, and hepatic steatosis in animal models by increasing energy expenditure through adipose tissue thermogenesis. This dual anti-inflammatory and metabolic profile makes Amlexanox a compound of significant research interest in obesity, diabetes, and chronic inflammatory conditions.
| Sequence / Structure | Non-peptide small molecule (2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid) |
| Molecular Weight | 298.29 g/mol |
| Purity | ≥99% |
| Appearance | White to yellowish crystalline powder |
| Storage | Store at room temperature, protect from light |
| Solubility | Soluble in DMSO |
Reilly SM, Chiang SH, Decker SJ, et al. (2013) — An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice. Nat Med. DOI: 10.1038/nm.3082
Oral EA, Reilly SM, Gomez AV, et al. (2017) — Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes. Cell Metab. DOI: 10.1016/j.cmet.2017.04.014
Amlexanox is a small molecule that inhibits the kinases IKKε and TBK1, showing promise in research for reversing obesity, insulin resistance, and chronic inflammation.
Our wholesale Amlexanox is ≥99% purity, verified by HPLC with full certificates of analysis.
Amlexanox is studied in metabolic research including obesity, type 2 diabetes, hepatic steatosis, and chronic inflammatory pathways.
Store at room temperature protected from light and moisture.
Contact our team for MOQ details and volume pricing on Amlexanox.
No, it is a small molecule compound commonly offered alongside peptide products due to overlapping research applications in metabolic science.
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