ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide derived from the erythropoietin (EPO) molecule, specifically engineered to activate the innate repair receptor (IRR) without erythropoietic effects. It represents a novel approach to tissue protection and repair through the EPO receptor/beta common receptor (βcR) heterodimer pathway. ARA-290 has demonstrated neuroprotective, anti-inflammatory, and tissue-protective properties in multiple clinical trials. We provide research-grade ARA-290 in lyophilized form for institutional research applications.
| Sequence | pGlu-Glu-Leu-Arg-Ala-Leu-Gly-Arg-Leu-Leu-Arg |
| Molecular Formula | C55H100N18O16 |
| Molecular Weight | 1257.50 g/mol |
| Purity | ≥98% (HPLC) |
| Form | Lyophilized powder |
| Storage | -20°C, desiccated |
| CAS | 1208243-50-8 |
Brines M et al. (2008) published in Proceedings of the National Academy of Sciences the discovery that ARA-290 activates the innate repair receptor without erythropoietic activity, opening a new therapeutic paradigm.
Heij L et al. (2012) demonstrated in Molecular Medicine that ARA-290 provides significant relief in sarcoidosis-associated small fiber neuropathy through neuronal protection and regeneration.
Clinical trial results published in Pain (2018) confirmed ARA-290's efficacy in reducing neuropathic pain scores and improving corneal nerve fiber density in diabetic patients.
ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide derived from erythropoietin that selectively activates the innate repair receptor (IRR). It promotes tissue protection and repair without stimulating red blood cell production.
We supply ARA-290 at ≥98% (HPLC) purity with full Certificate of Analysis including mass spectrometry and amino acid analysis verification.
ARA-290 selectively activates the IRR (EPO receptor/βcR heterodimer) responsible for tissue repair, without activating the classical EPO receptor homodimer that stimulates erythropoiesis. This provides tissue-protective effects without blood-related side effects.
MOQ for ARA-290 depends on the quantity required. Contact our sales team for specific pricing and availability.
Store ARA-290 at -20°C in lyophilized form. After reconstitution, store at 2-8°C and use within 7 days. ARA-290 is sensitive to oxidation, so minimize exposure to air.
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