B7-33 is an experimental single-chain peptide analog of human relaxin-2 that acts as a biased agonist at the relaxin family peptide receptor 1 (RXFP1). Unlike the native two-chain relaxin molecule, B7-33 selectively activates specific downstream signaling pathways (particularly pERK) while avoiding others, providing a unique pharmacological profile. Research suggests B7-33 may offer analgesic properties comparable to opioids without addiction potential, as well as anti-fibrotic effects. This makes it a compound of intense research interest in pain management, fibrosis, and cardiovascular therapeutics.
| Sequence / Structure | Single-chain relaxin B-chain analog |
| Molecular Weight | ~3,500 g/mol |
| Purity | ≥95% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from moisture |
| Solubility | Soluble in sterile water or PBS |
Hossain MA, Kocan M, Yao ST, et al. (2016) — A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chem Sci. DOI: 10.1039/C5SC04754D
Kocan M, Sarwar M, Hossain MA, et al. (2014) — Signalling profiles of H3 relaxin, H2 relaxin and R3(B∆23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3). Br J Pharmacol. DOI: 10.1111/bph.12623
B7-33 is a single-chain peptide analog of relaxin-2 that selectively activates RXFP1 receptor pathways, showing potential for analgesic and anti-fibrotic effects in preclinical research.
Our wholesale B7-33 is manufactured to ≥95% purity with full certificates of analysis.
B7-33 is used in research on pain signaling, fibrosis, biased GPCR agonism, and cardiovascular therapeutics.
Store at -20°C protected from moisture. After reconstitution, use within 7 days at 2-8°C.
Contact our sales team for MOQ and volume pricing details.
No, B7-33 is strictly an experimental research compound in early stages of investigation.
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