Bremelanotide Sulfonate is the sulfonate salt form of Bremelanotide (PT-141), a synthetic cyclic heptapeptide melanocortin receptor agonist. This modified salt form offers improved stability and aqueous solubility compared to the acetate form, making it preferred for certain research formulations. Like standard PT-141, Bremelanotide Sulfonate activates melanocortin receptors (particularly MC3R and MC4R) in the central nervous system, and has been extensively studied for its effects on sexual arousal, desire, and related neurological pathways. The original compound was FDA-approved in 2019 as Vyleesi for treatment of hypoactive sexual desire disorder.
| Sequence / Structure | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (sulfonate salt) |
| Molecular Weight | ~1,025 g/mol (free base) |
| Purity | ≥98% |
| Appearance | White to off-white lyophilized powder |
| Storage | Store at -20°C, protect from light and moisture |
| Solubility | Soluble in sterile water, bacteriostatic water |
Clayton AH, Althof SE, Kingsberg S, et al. (2016) — Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Womens Health. DOI: 10.2217/whe-2016-0018
Kingsberg SA, Clayton AH, Portman D, et al. (2019) — Bremelanotide for the treatment of hypoactive sexual desire disorder. Obstet Gynecol. DOI: 10.1097/AOG.0000000000003500
It is the sulfonate salt form of Bremelanotide (PT-141), offering improved stability and solubility. It acts as a melanocortin receptor agonist studied primarily for sexual function research.
The sulfonate salt form provides enhanced aqueous solubility and improved storage stability compared to the acetate salt, while maintaining identical pharmacological activity.
Our wholesale Bremelanotide Sulfonate is ≥98% purity with HPLC and MS verification.
Store at -20°C protected from light and moisture. Reconstituted solutions should be refrigerated and used within 14 days.
Contact our sales team for MOQ and bulk pricing details.
It contains the same active peptide but this is a research-grade sulfonate salt form, not the branded pharmaceutical product.
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