Colivelin is a hybrid peptide that combines an activity-dependent neurotrophic factor (ADNF)-derived sequence (SALLRSIPA) with a potent humanin derivative (AGA-HNG17). This fusion creates a peptide with synergistic neuroprotective activity that is significantly more potent than either component alone, showing promise in Alzheimer disease and neurodegenerative models.
| Sequence / Structure | SALLRSIPA-AGA(C8R)HNG17 hybrid sequence |
| Molecular Weight | ~2800 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Chiba T, Yamada M, Sasabe J, et al. (2009) — Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol Psychiatry. DOI: 10.1038/mp.2008.105
Matsuoka M. (2009) — Humanin; a defender against Alzheimer disease?. Recent Pat CNS Drug Discov. DOI: 10.2174/157488909789104848
Chiba T, Yamada M, Hashimoto Y, et al. (2005) — Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus. J Neurosci. DOI: 10.1523/JNEUROSCI.1348-05.2005
A hybrid peptide combining ADNF and humanin derivative sequences for synergistic neuroprotection.
Activates both STAT3 and humanin signaling pathways simultaneously for enhanced neuroprotective efficacy.
>=98% with certificates of analysis.
Alzheimer disease, neuroprotection, memory enhancement, and neurodegenerative disease models.
Lyophilized at -20C, reconstituted at 2-8C.
Yes, competitive bulk pricing available.
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