Desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP) is a synthetic analog of the natural antidiuretic hormone vasopressin (ADH). Through strategic molecular modifications — deamination at position 1 and D-arginine substitution at position 8 — Desmopressin exhibits dramatically enhanced antidiuretic potency, prolonged duration of action, and negligible vasopressor activity compared to native vasopressin. It is one of the most widely prescribed peptide drugs globally, used for treating diabetes insipidus, nocturnal enuresis, and certain bleeding disorders (hemophilia A, von Willebrand disease) by promoting factor VIII and von Willebrand factor release from endothelial stores.
| Sequence / Structure | Mpa-D-Tyr(Et)-Phe-D-Asn-Cys-Pro-D-Arg-Gly-NH2 (disulfide bridge) |
| Molecular Weight | 1,069.22 g/mol |
| Purity | ≥99% |
| Appearance | White lyophilized powder |
| Storage | Store at 2-8°C, protect from light |
| Solubility | Freely soluble in water and saline |
Mannucci PM, Ruggeri ZM, Pareti FI, et al. (1977) — 1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrand diseases. Lancet. DOI: 10.1016/S0140-6736(77)91507-0
Richardson DW, Robinson AG. (1985) — Desmopressin. Ann Intern Med. DOI: 10.7326/0003-4819-103-2-228
Desmopressin (DDAVP) is a synthetic analog of vasopressin with enhanced antidiuretic activity and minimal vasopressor effects, widely used in research on water balance and hemostasis.
Our wholesale Desmopressin is ≥99% purity with full analytical documentation.
Research applications include V2 receptor pharmacology, renal water handling, coagulation factor release, and hemostasis mechanism studies.
Store at 2-8°C protected from light. Reconstituted solutions should be used promptly.
Contact our team for wholesale pricing and MOQ details.
Desmopressin has 10x greater antidiuretic potency, minimal pressor effect, and significantly longer duration of action compared to natural vasopressin due to its structural modifications.
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