Dulaglutide is a long-acting GLP-1 receptor agonist consisting of a modified GLP-1 analog covalently linked to a modified human IgG4 Fc fragment via a small peptide linker. This fusion protein design provides a half-life of approximately 5 days, enabling once-weekly administration for diabetes and metabolic research.
| Sequence / Structure | GLP-1 analog fused to modified IgG4 Fc domain |
| Molecular Weight | ~59,670 g/mol |
| Purity | ≥95% |
| Appearance | White to off-white lyophilized powder |
| Storage | Store at -20°C, reconstituted at 2-8°C |
| Solubility | Soluble in aqueous buffers |
Gerstein HC, Colhoun HM, Dagenais GR, et al. (2019) — Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND). Lancet. DOI: 10.1016/S0140-6736(19)31149-3
Grunberger G, Chang A, Garcia Soria G, et al. (2015) — Monotherapy with the once-weekly GLP-1 analogue dulaglutide for 12 weeks in patients with Type 2 diabetes. J Diabetes Complications. DOI: 10.1016/j.jdiacomp.2015.05.013
Barrington P, Chien JY, Showalter HD, et al. (2011) — A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes. Diabetes Obes Metab. DOI: 10.1111/j.1463-1326.2011.01391.x
Dulaglutide is a GLP-1 receptor agonist designed as an Fc fusion protein, combining a modified GLP-1 peptide with a human IgG4 Fc fragment for extended half-life.
The IgG4 Fc fragment enables FcRn-mediated recycling, extending the circulating half-life to approximately 5 days and allowing once-weekly dosing.
Our Dulaglutide is supplied at ≥95% purity with comprehensive quality documentation.
Store at -20°C in lyophilized form. Reconstituted solutions should be refrigerated at 2-8°C and used within the validated timeframe.
Dulaglutide is studied in diabetes research, cardiovascular outcomes, weight management, Fc fusion protein engineering, and GLP-1 receptor pharmacology.
Yes, we offer wholesale quantities with volume-based pricing. Contact our team for specific quotations.
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