Dynorphin A is a 17-amino acid endogenous opioid peptide derived from the prodynorphin precursor protein. It is the most potent endogenous ligand for the kappa-opioid receptor (KOR), playing critical roles in pain modulation, stress responses, reward processing, and mood regulation. Unlike mu-opioid receptor agonists that produce euphoria, dynorphin/KOR signaling is associated with dysphoria, stress-induced analgesia, and aversive states. Dysregulation of the dynorphin system has been implicated in depression, addiction, chronic pain, and neurodegeneration, making Dynorphin A an essential research tool in neuropharmacology and pain science.
| Sequence / Structure | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln |
| Molecular Weight | 2,147.50 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from moisture and light |
| Solubility | Soluble in water and dilute acetic acid |
Chavkin C, James IF, Goldstein A. (1982) — Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science. DOI: 10.1126/science.6121376
Bruchas MR, Land BB, Chavkin C. (2010) — The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. DOI: 10.1016/j.brainres.2009.08.062
Dynorphin A is a 17-amino acid endogenous opioid peptide that potently activates kappa-opioid receptors, involved in pain modulation, stress responses, and mood regulation.
Our wholesale Dynorphin A is ≥98% purity with HPLC and MS verification.
Research areas include KOR pharmacology, pain signaling, stress-induced behaviors, addiction neuroscience, and mood disorder mechanisms.
Store at -20°C protected from moisture and light. Reconstituted solutions should be aliquoted and frozen.
Contact our sales team for MOQ and bulk pricing.
Unlike enkephalins and endorphins (mu-selective), Dynorphin A preferentially activates kappa-opioid receptors, mediating dysphoric and stress-related rather than euphoric responses.
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