Endomorphin-1 is a tetrapeptide (Tyr-Pro-Trp-Phe-NH2) identified as the most selective endogenous agonist of the mu-opioid receptor. It exhibits exceptional selectivity for mu over delta and kappa receptors and is distributed throughout the brain, particularly in regions associated with pain processing, reward, and autonomic function.
| Sequence / Structure | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 610.71 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Zadina JE, Hackler L, Ge LJ, et al. (1997) — A potent and selective endogenous agonist for the mu-opiate receptor. Nature. DOI: 10.1038/386499a0
Fichna J, Janecka A, Costentin J, et al. (2007) — The endomorphin system and its evolving neurophysiological role. Pharmacol Rev. DOI: 10.1124/pr.59.1.3
Zadina JE. (2002) — Isolation and distribution of endomorphins in the central nervous system. Jpn J Pharmacol. DOI: 10.1254/jjp.89.203
A tetrapeptide and the most selective endogenous mu-opioid receptor agonist, involved in pain modulation and reward.
Endomorphin-1 shows 4000-15000 fold selectivity for mu over delta and kappa opioid receptors.
>=98% with full certificates of analysis.
Mu-opioid pharmacology, pain research, reward circuits, and analgesic development.
Lyophilized at -20C, reconstituted at 2-8C.
Yes, competitive pricing with volume discounts.
Potent cognitive-enhancing peptide derived from angiotensin IV......
View Details Research PeptidesSynthetic ACTH analog nootropic peptide for cognitive enhancement......
View Details Research PeptidesAnxiolytic peptide derived from tuftsin with nootropic properties......
View Details Research PeptidesMitochondrial-derived peptide that regulates metabolic homeostasis......
View Details