Gastrin is a peptide hormone primarily produced by G cells in the gastric antrum and duodenum, existing in several molecular forms (G-34, G-17, G-14). It is the principal hormonal stimulator of gastric acid secretion, acting on CCK-B/gastrin receptors on parietal cells and enterochromaffin-like (ECL) cells to promote acid production and histamine release. Beyond its digestive role, Gastrin serves as a trophic factor for gastrointestinal mucosa and has been implicated in the pathophysiology of Zollinger-Ellison syndrome, gastric carcinogenesis, and colorectal cancer, making it a critical research tool in gastroenterology and oncology.
| Sequence / Structure | pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 |
| Molecular Weight | 2,098.24 g/mol (G-17) |
| Purity | ≥97% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from moisture |
| Solubility | Soluble in water and dilute ammonia |
Dockray GJ. (1999) — Topical review. Gastrin and gastric epithelial physiology. J Physiol. DOI: 10.1111/j.1469-7793.1999.0315t.x
Rehfeld JF. (2020) — Gastrin and colorectal cancer: a never-ending enigmatic association. Scand J Gastroenterol. DOI: 10.1080/00365521.2020.1733078
Gastrin is a peptide hormone that stimulates gastric acid secretion and mucosal growth in the GI tract. It is produced by G cells and acts through CCK-B/gastrin receptors.
Our wholesale Gastrin (G-17) is ≥97% purity with full analytical documentation.
Gastrin is used in gastric physiology, acid secretion studies, GI cancer research, and CCK-B receptor pharmacology.
Store at -20°C protected from moisture. Reconstituted solutions should be aliquoted and stored at -20°C.
Contact our sales team for MOQ and bulk pricing.
We supply Gastrin-17 (G-17, 'little gastrin'), the most physiologically active form, also available as pentagastrin upon request.
Potent cognitive-enhancing peptide derived from angiotensin IV......
View Details Research PeptidesSynthetic ACTH analog nootropic peptide for cognitive enhancement......
View Details Research PeptidesAnxiolytic peptide derived from tuftsin with nootropic properties......
View Details Research PeptidesMitochondrial-derived peptide that regulates metabolic homeostasis......
View Details