Growth Differentiation Factor 11 (GDF-11) is a member of the TGF-beta superfamily that has attracted significant attention as a potential circulating rejuvenation factor. Research suggests it declines with age and may play roles in cardiac, skeletal muscle, and brain rejuvenation, though its precise role in aging remains an active area of investigation.
| Sequence / Structure | TGF-beta superfamily member (mature form ~12.5 kDa monomer) |
| Molecular Weight | ~25 kDa (dimer) |
| Purity | >=95% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Loffredo FS, Steinhauser ML, Jay SM, et al. (2013) — Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. DOI: 10.1016/j.cell.2013.04.015
Katsimpardi L, Litterman NK, Schein PA, et al. (2014) — Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. DOI: 10.1126/science.1251141
Sinha M, Jang YC, Oh J, et al. (2014) — Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. DOI: 10.1126/science.1251152
GDF-11 is a TGF-beta superfamily member studied as a potential circulating rejuvenation factor that may reverse age-related tissue decline.
Research from parabiosis experiments suggests GDF-11 in young blood may reverse age-related cardiac, muscular, and neurological decline.
Our wholesale GDF-11 is >=95% pure with full quality documentation.
GDF-11 is studied in aging, cardiac regeneration, muscle rejuvenation, neurogenesis, and stem cell biology.
Store at -20C to -80C. Reconstituted solutions at 2-8C for short-term use.
Yes, we offer competitive wholesale pricing with volume discounts.
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