GW501516 (also known as Cardarine or Endurobol) is a potent and selective agonist of peroxisome proliferator-activated receptor delta (PPARδ), originally developed by GlaxoSmithKline and Ligand Pharmaceuticals for treatment of metabolic and cardiovascular diseases. PPARδ activation drives fatty acid oxidation, enhances endurance capacity, improves lipid profiles, and reduces inflammation. In preclinical studies, GW501516 dramatically increased running endurance in sedentary mice by reprogramming muscle fiber type composition. Clinical development was discontinued due to concerns about rapid cancer development in animal studies at high doses, but it remains widely used as a research tool for studying PPARδ-mediated metabolic pathways.
| Sequence / Structure | Non-peptide small molecule PPARδ agonist |
| Molecular Weight | 453.50 g/mol |
| Purity | ≥99% |
| Appearance | White to light yellow powder |
| Storage | Store at room temperature, protect from light |
| Solubility | Soluble in DMSO and ethanol |
Narkar VA, Downes M, Yu RT, et al. (2008) — AMPK and PPARdelta agonists are exercise mimetics. Cell. DOI: 10.1016/j.cell.2008.06.051
Wang YX, Zhang CL, Yu RT, et al. (2004) — Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. DOI: 10.1371/journal.pbio.0020294
GW501516 (Cardarine) is a selective PPARδ agonist that enhances fatty acid oxidation and endurance capacity. It was developed for metabolic diseases but clinical trials were discontinued.
Our wholesale GW501516 is ≥99% purity with HPLC verification.
GW501516 is used in PPARδ signaling research, endurance physiology, lipid metabolism, and fatty acid oxidation studies.
Store at room temperature protected from light and moisture.
Contact our team for bulk pricing and MOQ details.
No, it is a non-peptide small molecule, commonly offered alongside research peptides due to overlapping performance research applications.
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