Human Menopausal Gonadotropin (HMG, Menotropin) is a preparation of gonadotropins extracted from the urine of postmenopausal women, containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity in approximately equal proportions. HMG stimulates ovarian follicular development (via FSH) and steroidogenesis (via LH), making it a cornerstone of assisted reproductive technology (ART). In research settings, HMG is invaluable for studying gonadal function, folliculogenesis, spermatogenesis, and the HPG axis. Clinically, it is used for ovulation induction and controlled ovarian hyperstimulation in IVF protocols.
| Sequence / Structure | Mixture of FSH and LH glycoproteins |
| Molecular Weight | ~30,000-40,000 g/mol (glycoprotein mixture) |
| Purity | ≥98% (75 IU FSH + 75 IU LH per vial typical) |
| Appearance | White to off-white lyophilized powder |
| Storage | Store at 2-8°C, protect from light |
| Solubility | Soluble in sterile water and saline |
Lunenfeld B. (2004) — Historical perspectives in gonadotrophin therapy. Hum Reprod Update. DOI: 10.1093/humupd/dmh044
Lehert P, Kolibianakis EM, Venetis CA, et al. (2014) — Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology. Cochrane Database Syst Rev. DOI: 10.1002/14651858.CD005070.pub3
HMG (Human Menopausal Gonadotropin) is a preparation containing both FSH and LH activity, used in fertility research and assisted reproductive technology studies.
Our wholesale HMG is ≥98% with standardized FSH and LH bioactivity (typically 75 IU each per vial).
HMG is used in fertility research, folliculogenesis, spermatogenesis studies, HPG axis research, and ovarian stimulation protocols.
Store at 2-8°C protected from light. Use reconstituted solutions within 24 hours.
Contact our team for MOQ and wholesale pricing.
HMG contains both FSH and LH activity, providing a more physiologically complete gonadotropin stimulus compared to purified FSH-only preparations.
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