Humanin is a 24-amino acid mitochondrial-derived peptide (MDP) encoded in the 16S ribosomal RNA gene of mitochondrial DNA. It was originally identified for its ability to suppress neuronal cell death in Alzheimer disease models. Research has expanded to show broad cytoprotective, anti-apoptotic, and metabolic regulatory functions across multiple organ systems.
| Sequence / Structure | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| Molecular Weight | 2687.2 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Hashimoto Y, Niikura T, Tajima H, et al. (2001) — A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer disease genes and Abeta. Proc Natl Acad Sci USA. DOI: 10.1073/pnas.101032498
Muzumdar RH, Huffman DM, Atzmon G, et al. (2009) — Humanin: a novel central regulator of peripheral insulin action. PLoS ONE. DOI: 10.1371/journal.pone.0006334
Lee C, Yen K, Cohen P. (2013) — Humanin: a harbinger of mitochondrial-derived peptides?. Trends Endocrinol Metab. DOI: 10.1016/j.tem.2013.01.005
Humanin is a 24-amino acid peptide encoded by mitochondrial DNA, originally discovered for its neuroprotective effects in Alzheimer disease models.
Humanin was identified in 2001 through a functional screen for factors that protect neurons from Alzheimer-associated amyloid beta toxicity.
Our wholesale Humanin is >=98% pure with complete certificates of analysis.
Humanin is studied in neuroprotection, aging, metabolic regulation, mitochondrial biology, and cytoprotective signaling.
Store lyophilized Humanin at -20C. Reconstituted solutions at 2-8C.
Yes, we provide competitive bulk pricing for Humanin with volume discounts.
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