Ibutamoren (MK-677) is a potent, orally active growth hormone secretagogue that stimulates the pituitary gland to release growth hormone by mimicking the action of ghrelin. Unlike injectable GH, MK-677 provides sustained GH and IGF-1 elevation with once-daily oral dosing, making it a highly sought-after compound for research into muscle wasting, bone density, sleep quality, and age-related GH decline.
| Sequence / Structure | Non-peptide GH secretagogue (small molecule) |
| Molecular Weight | 528.67 g/mol |
| Purity | ≥99% |
| Appearance | White to off-white crystalline powder |
| Storage | Store at room temperature, protect from moisture |
| Solubility | Soluble in DMSO, ethanol |
Nass R, Pezzoli SS, Oliveri MC, et al. (2008) — Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Ann Intern Med. DOI: 10.7326/0003-4819-149-9-200811040-00003
Murphy MG, Plunkett LM, Gertz BJ, et al. (1998) — MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab. DOI: 10.1210/jcem.83.2.4551
Copinschi G, Leproult R, Van Onderbergen A, et al. (1997) — Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. DOI: 10.1159/000127262
Ibutamoren, also known as MK-677, is a non-peptide, orally active growth hormone secretagogue that stimulates the release of growth hormone from the pituitary gland by mimicking the action of the hunger hormone ghrelin.
Unlike recombinant GH injections, MK-677 is taken orally and works by stimulating the body's own GH production via the ghrelin receptor, maintaining the natural pulsatile release pattern and feedback mechanisms.
Our wholesale MK-677 is manufactured to ≥99% purity, verified by HPLC analysis with full certificates of analysis provided with every batch.
MK-677 is widely studied in research on muscle wasting, sarcopenia, bone mineral density, sleep architecture, GH-deficient states, and metabolic parameters.
MK-677 should be stored at room temperature in a dry environment, protected from moisture and light. Under proper storage, it maintains stability for extended periods.
We offer flexible wholesale pricing tiers. Contact our sales team for MOQ details and volume-based discounts on MK-677.
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