Insulin-like Growth Factor 1 (IGF-1, Somatomedin C) is a 70-amino acid single-chain polypeptide with structural similarity to insulin that serves as the primary mediator of growth hormone's (GH) anabolic effects. Produced mainly in the liver under GH stimulation, IGF-1 circulates bound to IGF-binding proteins (IGFBPs) and acts through the IGF-1 receptor (IGF-1R), a tyrosine kinase receptor that activates PI3K/Akt and MAPK/ERK pathways. IGF-1 promotes cell growth, differentiation, and survival in virtually all tissues, playing critical roles in linear growth, muscle hypertrophy, bone metabolism, neuronal survival, and metabolic regulation. Dysregulation of IGF-1 signaling is implicated in cancer, diabetes, and aging.
| Sequence / Structure | 70-amino acid single-chain polypeptide (3 disulfide bonds) |
| Molecular Weight | 7,649 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from light; avoid repeated freeze-thaw |
| Solubility | Soluble in sterile water (10 mM HCl recommended) |
LeRoith D, Yakar S. (2007) — Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab. DOI: 10.1038/ncpendmet0427
Clemmons DR. (2009) — Role of IGF-I in skeletal muscle mass maintenance. Trends Endocrinol Metab. DOI: 10.1016/j.tem.2009.04.002
IGF-1 is a 70-amino acid peptide hormone that mediates most of growth hormone's anabolic effects, promoting cell growth and survival through the IGF-1 receptor.
Our wholesale IGF-1 is ≥98% purity, verified by HPLC and mass spectrometry.
IGF-1 is used in GH/IGF-1 axis studies, muscle physiology, cancer biology, bone metabolism, neuronal survival, and aging research.
Store at -20°C protected from light. Reconstitute in 10 mM HCl, aliquot, and avoid repeated freeze-thaw cycles.
Contact our team for MOQ and volume pricing.
HGH is the upstream hormone produced by the pituitary, while IGF-1 is its downstream effector produced primarily in the liver. Many of GH's growth-promoting effects are mediated through IGF-1 production.
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