Leuprolide (Leuprorelin) is a synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a potent GnRH receptor super-agonist. Upon initial administration, Leuprolide causes a transient increase in gonadotropin (LH, FSH) secretion ('flare effect'), followed by sustained downregulation and desensitization of pituitary GnRH receptors, resulting in profound suppression of gonadal steroid production. This biphasic pharmacological profile has made Leuprolide one of the most widely prescribed GnRH agonists, used clinically for prostate cancer, endometriosis, uterine fibroids, central precocious puberty, and as part of IVF protocols. It is available in daily injection and depot formulations.
| Sequence / Structure | pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt |
| Molecular Weight | 1,209.40 g/mol |
| Purity | ≥99% |
| Appearance | White lyophilized powder |
| Storage | Store at 2-8°C, protect from light |
| Solubility | Soluble in sterile water and saline |
Wilson AC, Vadakkadath Meethal S, Bowen RL, et al. (2007) — Leuprolide acetate: a drug of diverse clinical applications. Expert Opin Investig Drugs. DOI: 10.1517/13543784.16.11.1851
Conn PM, Crowley WF Jr. (1991) — Gonadotropin-releasing hormone and its analogues. N Engl J Med. DOI: 10.1056/NEJM199101243240405
Leuprolide is a synthetic GnRH super-agonist that initially stimulates, then profoundly suppresses gonadotropin secretion through receptor desensitization.
Our wholesale Leuprolide is ≥99% purity with full analytical documentation.
Applications include GnRH receptor pharmacology, prostate cancer, reproductive endocrinology, endometriosis, and HPG axis research.
Store at 2-8°C protected from light. Reconstituted solutions should be used within 24 hours.
Contact our team for MOQ and volume pricing.
Leuprolide (agonist) initially stimulates gonadotropin release before suppression, while antagonists provide immediate suppression without the initial flare.
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