Orexin-A (Hypocretin-1) is a 33-amino acid neuropeptide produced by neurons in the lateral hypothalamus. It plays essential roles in maintaining wakefulness, regulating arousal, and modulating feeding behavior. Orexin deficiency causes narcolepsy, making it a critical research target in sleep medicine, neurology, and metabolic regulation.
| Sequence / Structure | 33-amino acid peptide with two intrachain disulfide bonds (pyroglutamyl N-terminus) |
| Molecular Weight | 3561.09 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Sakurai T, Amemiya A, Ishii M, et al. (1998) — Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. DOI: 10.1016/S0092-8674(00)81400-5
de Lecea L, Kilduff TS, Peyron C, et al. (1998) — The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA. DOI: 10.1073/pnas.95.1.322
Scammell TE, Winrow CJ. (2011) — Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. DOI: 10.1146/annurev-pharmtox-010510-100528
A 33-amino acid neuropeptide from the lateral hypothalamus essential for wakefulness, arousal, and feeding regulation.
Orexin deficiency causes narcolepsy type 1, characterized by excessive daytime sleepiness, cataplexy, and disrupted sleep architecture.
>=98% with full certificates of analysis.
Sleep medicine, narcolepsy, arousal, appetite regulation, addiction, and metabolic research.
Lyophilized at -20C, reconstituted at 2-8C.
Yes, competitive pricing with volume discounts.
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