P21, also known as P021, is a small peptide derived from the ciliary neurotrophic factor (CNTF). It acts as a CNTF small-molecule peptidomimetic that inhibits leukemia inhibitory factor (LIF) signaling while promoting BDNF expression and neurogenesis. Research shows promise in Alzheimer's disease models, cognitive enhancement, and neurodegenerative conditions.
| Sequence / Structure | Ac-DGGL-Aib-G-NH2 (CNTF-derived sequence) |
| Molecular Weight | ~900 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, reconstituted at 2-8°C |
| Solubility | Soluble in water |
Bolognin S, Buffelli M, Bhatt DK, et al. (2014) — A neurotrophic compound P021 in combination with bone marrow mesenchymal stem cells improves cognition in mouse model of Alzheimer's disease. Mol Neurobiol. DOI: 10.1007/s12035-014-8697-y
Kazim SF, Iqbal K. (2016) — Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease. Mol Neurodegener. DOI: 10.1186/s13024-016-0119-y
Li B, Wanka L, Blanber J, et al. (2010) — Neurotrophic peptides incorporating adamantane improve learning and memory in aged mice. Aging Cell. DOI: 10.1111/j.1474-9726.2010.00590.x
P21 (P021) is a CNTF-derived peptide that promotes neurogenesis, BDNF expression, and cognitive function while inhibiting LIF signaling.
P21 enhances BDNF expression and promotes hippocampal neurogenesis by modulating the CNTF/LIF signaling pathway, supporting new neuron formation and synaptic plasticity.
Our wholesale P21 is ≥98% pure with comprehensive analytical documentation.
P21 is studied in Alzheimer's disease, cognitive decline, neurogenesis, memory enhancement, and neurodegenerative conditions.
Store lyophilized P21 at -20°C. Reconstituted solutions at 2-8°C.
Yes, we offer competitive bulk pricing for P21 with volume discounts.
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