Retatrutide (LY3437943) is a first-in-class triple agonist peptide targeting GIP, GLP-1, and glucagon receptors simultaneously. This novel approach provides additive metabolic benefits by combining appetite suppression (GLP-1), enhanced fat metabolism (glucagon), and improved insulin sensitivity (GIP). Phase 2 trials demonstrated unprecedented weight loss of up to 24% over 48 weeks.
| Sequence / Structure | 39-amino acid triple agonist with C-20 fatty acid modification |
| Molecular Weight | ~5100 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Jastreboff AM, Kaplan LM, Frias JP, et al. (2023) — Triple-hormone-receptor agonist retatrutide for obesity. N Engl J Med. DOI: 10.1056/NEJMoa2301972
Rosenstock J, Frias J, Jastreboff AM, et al. (2023) — Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes. Lancet. DOI: 10.1016/S0140-6736(23)01053-X
Coskun T, Urva S, Roell WC, et al. (2022) — LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1 trial. Lancet. DOI: 10.1016/S0140-6736(22)01401-0
Retatrutide is a first-in-class triple hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors for enhanced metabolic effects.
GLP-1 activation reduces appetite, GIP improves insulin sensitivity, and glucagon receptor activation enhances energy expenditure and fat oxidation, providing synergistic metabolic benefits.
Our wholesale Retatrutide is >=98% pure with comprehensive analytical documentation.
While Tirzepatide is a dual GIP/GLP-1 agonist, Retatrutide adds glucagon receptor activation, showing superior weight loss in comparative studies.
Store lyophilized Retatrutide at -20C. Reconstituted solutions at 2-8C.
Yes, we offer competitive bulk pricing for Retatrutide with volume discounts.
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