Secretin is a 27-amino acid peptide hormone produced by S cells of the duodenal and jejunal mucosa, historically significant as the first hormone ever discovered (by Bayliss and Starling in 1902). Secretin is released in response to acidic chyme entering the duodenum and acts primarily on pancreatic ductal cells to stimulate secretion of bicarbonate-rich fluid, neutralizing gastric acid. It also inhibits gastric acid secretion, stimulates bile flow, and regulates water homeostasis. In clinical practice, synthetic secretin is used as a diagnostic agent in the secretin stimulation test for Zollinger-Ellison syndrome and pancreatic exocrine function evaluation.
| Sequence / Structure | His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 |
| Molecular Weight | 3,055.47 g/mol |
| Purity | ≥97% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from moisture |
| Solubility | Soluble in sterile water and saline |
Chey WY, Chang TM. (2003) — Secretin, 100 years later. J Gastroenterol. DOI: 10.1007/s00535-003-1214-0
Afroze S, Meng F, Jensen K, et al. (2013) — The physiological roles of secretin and its receptor. Ann Transl Med. DOI: 10.3978/j.issn.2305-5839.2013.01.01
Secretin is a 27-amino acid GI hormone — the first hormone ever discovered — that stimulates pancreatic bicarbonate secretion and regulates gastric acid output.
Our wholesale Secretin is ≥97% purity with full analytical documentation.
Secretin is used in pancreatic physiology, GI hormone research, diagnostic test development, and acid-base regulation studies.
Store at -20°C protected from moisture. Reconstituted solutions should be used promptly.
Contact our team for MOQ and volume pricing.
Discovered in 1902 by Bayliss and Starling, Secretin was the first substance identified as a 'hormone,' establishing the field of endocrinology.
Body Protection Compound-157 — a pentadecapeptide for systemic and localized tissue healing......
View Details Pharmaceutical PeptidesHighly selective growth hormone releasing peptide (GHRP) with minimal side effects......
View Details Pharmaceutical PeptidesGHRH analog that stimulates natural growth hormone production for anti-aging research......
View Details Pharmaceutical PeptidesSynthetic fragment of Thymosin Beta-4 for tissue repair and regeneration research......
View Details