Seliciclib (R-Roscovitine, CYC202) is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), primarily targeting CDK2/cyclin E, CDK7/cyclin H, and CDK9/cyclin T1. By blocking these key cell cycle regulators, Seliciclib arrests cell proliferation, induces apoptosis in cancer cells, and modulates transcription. Originally developed as an anti-cancer agent, Seliciclib has undergone Phase II clinical trials for non-small cell lung cancer and nasopharyngeal carcinoma. Beyond oncology, it shows promise in research on inflammatory diseases, viral infections (by inhibiting CDK9-dependent viral transcription), and neurodegenerative conditions.
| Sequence / Structure | Non-peptide small molecule (2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine) |
| Molecular Weight | 354.44 g/mol |
| Purity | ≥99% |
| Appearance | Off-white to pale yellow powder |
| Storage | Store at -20°C, protect from light |
| Solubility | Soluble in DMSO and ethanol |
Meijer L, Borgne A, Mulner O, et al. (1997) — Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2, cdk5, and cdk7. Eur J Biochem. DOI: 10.1111/j.1432-1033.1997.0527a.x
Benson C, White J, De Bono J, et al. (2007) — A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer. DOI: 10.1038/sj.bjc.6603461
Seliciclib (Roscovitine) is a selective CDK2/7/9 inhibitor that blocks cell proliferation and induces apoptosis, studied primarily as an anti-cancer compound.
Our wholesale Seliciclib is ≥99% purity with HPLC verification.
Applications include CDK biology, cell cycle research, anti-cancer studies, transcription regulation, and anti-viral research.
Store at -20°C protected from light. Prepare stock solutions in DMSO.
Contact our team for MOQ and bulk pricing.
No, it is a purine-based small molecule CDK inhibitor, commonly offered alongside peptide products for overlapping research applications.
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