Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist with 94% structural homology to native GLP-1. It features an acylated side chain enabling albumin binding for extended half-life (~7 days). Approved for type 2 diabetes and chronic weight management, it represents one of the most impactful peptide therapeutics in modern medicine.
| Sequence / Structure | Modified GLP-1 analog with Aib8, Arg34, C-18 fatty diacid at Lys26 |
| Molecular Weight | 4113.58 g/mol |
| Purity | ≥98% |
| Appearance | White to off-white lyophilized powder |
| Storage | Store at -20°C, reconstituted at 2-8°C |
| Solubility | Soluble in water at pH 7-8 |
Marso SP, Bain SC, Consoli A, et al. (2016) — Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. DOI: 10.1056/NEJMoa1607141
Wilding JPH, Batterham RL, Calanna S, et al. (2021) — Once-weekly semaglutide in adults with overweight or obesity. N Engl J Med. DOI: 10.1056/NEJMoa2032183
Lau J, Bloch P, Schaffer L, et al. (2015) — Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide. J Med Chem. DOI: 10.1021/acs.jmedchem.5b00726
Semaglutide is a long-acting GLP-1 receptor agonist peptide with a modified structure enabling once-weekly dosing, used in research on diabetes, obesity, and cardiovascular disease.
Semaglutide activates GLP-1 receptors to enhance glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system signaling.
Our wholesale Semaglutide is ≥98% pure with full analytical documentation including HPLC, MS, and amino acid analysis.
Lyophilized Semaglutide should be stored at -20°C. Reconstituted solutions should be refrigerated at 2-8°C.
Semaglutide features superior albumin binding via its C-18 fatty diacid modification, providing the longest half-life among GLP-1 agonists (~7 days) and enhanced clinical efficacy.
Yes, we provide competitive wholesale pricing with volume-based discounts. Contact our team for custom quotes on Semaglutide orders.
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