Somatostatin (SST, also known as Growth Hormone Inhibiting Hormone or Somatotropin Release Inhibiting Factor) is a cyclic 14-amino acid peptide hormone produced throughout the body, primarily in the hypothalamus, pancreatic delta cells, and gastrointestinal D cells. Acting through five G protein-coupled receptor subtypes (SSTR1-5), Somatostatin functions as a universal endocrine 'off switch,' inhibiting the secretion of growth hormone, TSH, insulin, glucagon, gastrin, secretin, and numerous other hormones. Clinically, synthetic somatostatin and its longer-acting analogs (octreotide, lanreotide) are used for treating acromegaly, neuroendocrine tumors, variceal bleeding, and diarrheal syndromes.
| Sequence / Structure | Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (disulfide bridge Cys3-Cys14) |
| Molecular Weight | 1,637.88 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from light and moisture |
| Solubility | Soluble in sterile water and dilute acetic acid |
Theodoropoulou M, Stalla GK. (2013) — Somatostatin receptors: from signaling to clinical practice. Front Neuroendocrinol. DOI: 10.1016/j.yfrne.2013.07.005
Brazeau P, Vale W, Burgus R, et al. (1973) — Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science. DOI: 10.1126/science.179.4068.77
Somatostatin is a cyclic 14-amino acid peptide that inhibits secretion of numerous hormones including GH, insulin, and glucagon, acting through 5 receptor subtypes (SSTR1-5).
Our wholesale Somatostatin is ≥98% purity with full analytical documentation.
Somatostatin is used in endocrine regulation, SSTR pharmacology, neuroendocrine tumor research, and GI physiology studies.
Store at -20°C protected from light and moisture. Reconstituted solutions are unstable — use within hours.
Contact our team for MOQ and volume pricing.
Native Somatostatin has a very short half-life (~2 min), while synthetic analogs like Octreotide are designed for much longer duration of action, making them more practical for clinical use.
Body Protection Compound-157 — a pentadecapeptide for systemic and localized tissue healing......
View Details Pharmaceutical PeptidesHighly selective growth hormone releasing peptide (GHRP) with minimal side effects......
View Details Pharmaceutical PeptidesGHRH analog that stimulates natural growth hormone production for anti-aging research......
View Details Pharmaceutical PeptidesSynthetic fragment of Thymosin Beta-4 for tissue repair and regeneration research......
View Details