SR9009 (Stenabolic) is a synthetic agonist of the nuclear receptor Rev-Erbα, a key component of the circadian clock machinery that links circadian rhythms to metabolic regulation. Developed at The Scripps Research Institute, SR9009 activates Rev-Erbα to modulate the expression of genes involved in lipid and glucose metabolism, mitochondrial biogenesis, and inflammatory responses. In animal studies, SR9009 increased exercise capacity, reduced fat mass, decreased plasma cholesterol and triglycerides, and altered circadian behavior patterns. Despite promising preclinical data, SR9009 has very low oral bioavailability, and no human clinical trials have been conducted.
| Sequence / Structure | Non-peptide small molecule Rev-Erbα agonist |
| Molecular Weight | 437.94 g/mol |
| Purity | ≥99% |
| Appearance | White to off-white powder |
| Storage | Store at room temperature, protect from light |
| Solubility | Soluble in DMSO and ethanol |
Solt LA, Wang Y, Banerjee S, et al. (2012) — Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. DOI: 10.1038/nature11030
Woldt E, Sebti Y, Solt LA, et al. (2013) — Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. DOI: 10.1038/nm.3213
SR9009 (Stenabolic) is a synthetic Rev-Erbα agonist that modulates circadian clock-controlled metabolic pathways, enhancing exercise capacity and fat metabolism in preclinical models.
Our wholesale SR9009 is ≥99% purity with HPLC verification.
SR9009 is used in circadian biology, Rev-Erbα signaling, metabolic regulation, and exercise physiology research.
Store at room temperature protected from light and moisture.
Contact our team for MOQ and bulk pricing.
SR9009 is neither — it is a Rev-Erbα agonist (small molecule). It is often misclassified as a SARM but has a completely different mechanism targeting circadian nuclear receptors.
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