SR9011 is a synthetic agonist of both Rev-Erbα and Rev-Erbβ nuclear receptors, developed as a more potent and improved analog of SR9009. By targeting both Rev-Erb isoforms, SR9011 provides enhanced modulation of circadian clock-regulated metabolic processes including lipid metabolism, glucose homeostasis, and mitochondrial function. In preclinical studies, SR9011 demonstrated improved oral bioavailability compared to SR9009, along with potent anxiolytic-like effects, altered sleep-wake patterns, and reduced diet-induced obesity. The compound serves as a valuable pharmacological tool for studying the intersection of circadian biology and metabolism.
| Sequence / Structure | Non-peptide small molecule dual Rev-Erb agonist |
| Molecular Weight | 479.04 g/mol |
| Purity | ≥99% |
| Appearance | White powder |
| Storage | Store at room temperature, protect from light |
| Solubility | Soluble in DMSO |
Solt LA, Wang Y, Banerjee S, et al. (2012) — Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. DOI: 10.1038/nature11030
Banerjee S, Wang Y, Solt LA, et al. (2014) — Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat Commun. DOI: 10.1038/ncomms6759
SR9011 is a dual Rev-Erbα/β agonist with improved potency over SR9009, modulating circadian-controlled metabolic processes and showing anxiolytic properties in preclinical studies.
Our wholesale SR9011 is ≥99% purity with HPLC verification.
SR9011 targets both Rev-Erbα and Rev-Erbβ (vs. primarily α for SR9009), has improved oral bioavailability, and shows additional anxiolytic-like activity.
Store at room temperature protected from light.
Contact our team for MOQ and pricing.
No, it is a non-peptide small molecule Rev-Erb agonist offered alongside peptide products for overlapping metabolic research applications.
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