Taltirelin is a synthetic analog of thyrotropin-releasing hormone (TRH) with improved metabolic stability and enhanced central nervous system activity. Unlike native TRH, it has minimal endocrine effects while maintaining potent CNS-stimulating properties. Approved in Japan for spinocerebellar degeneration and studied for various neurological conditions.
| Sequence / Structure | Modified TRH analog (1-methyl-4,5-dihydroorotyl-His-Pro-NH2) |
| Molecular Weight | 475.54 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20C, reconstituted at 2-8C |
| Solubility | Soluble in water |
Kinoshita K, Watanabe Y, Asai H, et al. (1998) — Taltirelin hydrate (TA-0910): an orally active thyrotropin-releasing hormone mimetic agent with multiple actions. CNS Drug Rev. DOI: 10.1111/j.1527-3458.1998.tb00057.x
Khomane KS, Meena CL, Jain R, et al. (2011) — Novel thyrotropin-releasing hormone analogs: a patent review. Expert Opin Ther Pat. DOI: 10.1517/13543776.2011.623127
Gary KA, Sevarino KA, Yarbrough GG, et al. (2003) — The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation. Pharmacol Ther. DOI: 10.1016/S0163-7258(03)00002-X
A TRH analog with enhanced CNS activity and minimal endocrine effects, approved in Japan for spinocerebellar degeneration.
Taltirelin has greater metabolic stability, enhanced CNS penetration, and reduced thyroid-stimulating activity compared to native TRH.
>=98% with full analytical certificates.
Spinocerebellar degeneration, CNS arousal, motor function, TRH pharmacology, and neurological research.
Lyophilized at -20C, reconstituted at 2-8C.
Yes, competitive pricing with volume discounts.
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