TB4-Frag, also known as Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline), is a naturally occurring tetrapeptide derived from the N-terminal sequence of Thymosin Beta-4. It is released by prolyl oligopeptidase and plays crucial roles in hematopoietic stem cell regulation, anti-fibrosis, and cardiovascular protection. Research demonstrates its potent anti-inflammatory and organ-protective properties.
| Sequence / Structure | Ac-Ser-Asp-Lys-Pro-OH |
| Molecular Weight | 487.51 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, reconstituted at 2-8°C |
| Solubility | Soluble in water |
Kanasaki K, Koya D, Sugimoto T, et al. (2003) — N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells. J Am Soc Nephrol. DOI: 10.1097/01.ASN.0000069223.96561.77
Sharma U, Rhaleb NE, Pokharel S, et al. (2008) — Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol. DOI: 10.1152/ajpheart.00305.2008
Cavasin MA, Liao TD, Yang XP, et al. (2007) — Decreased endogenous levels of Ac-SDKP promote organ fibrosis. Hypertension. DOI: 10.1161/01.HYP.0000254826.96500.3b
TB4-Frag (Ac-SDKP) is a naturally occurring tetrapeptide derived from the N-terminus of Thymosin Beta-4, with potent anti-fibrotic and anti-inflammatory properties.
Ac-SDKP is released from Thymosin Beta-4 by the enzyme prolyl oligopeptidase (POP) and is normally degraded by angiotensin-converting enzyme (ACE).
Our wholesale TB4-Frag is ≥98% pure with full analytical documentation.
Ac-SDKP is studied in anti-fibrotic therapy, stem cell regulation, cardiovascular protection, and renal disease research.
Store lyophilized TB4-Frag at -20°C. Reconstituted solutions should be kept at 2-8°C.
Yes, we offer wholesale pricing with flexible quantities and volume discounts.
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