Tesofensine is a novel serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI) originally developed for neurodegenerative diseases but redirected to obesity research after significant weight loss was observed in trials. It suppresses appetite and increases energy expenditure through central monoamine modulation.
| Sequence / Structure | Non-peptide small molecule (C17H23Cl2NO3) |
| Molecular Weight | 396.4 g/mol |
| Purity | >=98% |
| Appearance | White lyophilized powder |
| Storage | Store at room temperature, protect from light |
| Solubility | Soluble in DMSO and ethanol |
Astrup A, Madsbad S, Breum L, et al. (2008) — Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients. Lancet. DOI: 10.1016/S0140-6736(08)61525-1
Sjodin A, Gasteyger C, Nielsen AL, et al. (2010) — The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men. Int J Obes. DOI: 10.1038/ijo.2010.87
Appel L, Bergstrom M, Buus Lassen J, et al. (2014) — Tesofensine, a novel triple monoamine reuptake inhibitor with anti-obesity effects. Curr Top Med Chem. DOI: 10.2174/1568026614666141016144042
Tesofensine is a triple monoamine reuptake inhibitor (SNDRI) that blocks the reuptake of serotonin, noradrenaline, and dopamine for appetite suppression and weight loss research.
By increasing synaptic levels of all three monoamines, Tesofensine reduces appetite and enhances energy expenditure through central nervous system mechanisms.
Our wholesale Tesofensine is >=98% pure with comprehensive analytical certificates.
Tesofensine showed approximately 2x greater weight loss than sibutramine in phase 2 trials, through its unique triple reuptake mechanism.
Store at room temperature, protected from light and moisture.
Yes, we provide competitive wholesale pricing for Tesofensine with volume discounts.
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