Pharmaceutical Peptides

Thymosin Alpha-1

Thymosin Alpha-1 (Tα1) is a 28-amino acid peptide naturally produced by the thymus gland that plays a crucial role in immune system regulation. It is approved in over 30 countries for the treatment of hepatitis B and C, and is extensively researched for immune enhancement in cancer, immunodeficiency, and infectious diseases. Tα1 acts by stimulating T-cell maturation, dendritic cell function, and antibody responses.

Technical Specifications

Sequence / StructureAc-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH
Molecular Weight3108.3 g/mol
Purity≥98%
AppearanceWhite lyophilized powder
StorageStore at -20°C, reconstituted at 2-8°C
SolubilityFreely soluble in water

Application Areas

  • Immune system modulation
  • Hepatitis B/C research
  • Cancer immunotherapy studies
  • Vaccine adjuvant research
  • Immunodeficiency research
  • Anti-aging immune support

Published Research on Thymosin Alpha-1

Tuthill C, Rios I, McBeath R. (2010) — Thymalfasin: an immune system enhancer for the treatment of viral hepatitis. Expert Opin Biol Ther. DOI: 10.1517/14712598.2010.481666

Garaci E, Pica F, Sinibaldi-Vallebona P, et al. (2003) — Thymosin alpha 1 in combination with cytokines and chemotherapy for the treatment of cancer. Int Immunopharmacol. DOI: 10.1016/S1567-5769(03)00034-2

Romani L, Bistoni F, Montagnoli C, et al. (2007) — Thymosin alpha 1: an endogenous regulator of inflammation, immunity, and tolerance. Ann N Y Acad Sci. DOI: 10.1196/annals.1409.023

Frequently Asked Questions About Thymosin Alpha-1

Thymosin Alpha-1 is a 28-amino acid peptide naturally produced by the thymus gland that plays a critical role in immune regulation, T-cell maturation, and dendritic cell activation.

Yes, Thymosin Alpha-1 (marketed as Zadaxin) is approved in over 30 countries worldwide for the treatment of hepatitis B, hepatitis C, and as an immune adjuvant.

Our wholesale Thymosin Alpha-1 is manufactured to ≥98% purity, confirmed by HPLC analysis with certificates of analysis included.

Lyophilized Thymosin Alpha-1 should be stored at -20°C for long-term stability. Once reconstituted, store at 2-8°C and use within 14 days.

Thymosin Alpha-1 is studied in immune modulation, viral hepatitis treatment, cancer immunotherapy, vaccine enhancement, and age-related immune decline.

Unlike Thymosin Beta-4 which focuses on tissue repair, Thymosin Alpha-1 is specifically involved in adaptive immune regulation and T-cell function.

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