Triptorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) with a D-Trp substitution at position 6, making it approximately 100 times more potent than native GnRH. Like other GnRH agonists, Triptorelin initially stimulates pituitary gonadotropin release before inducing receptor downregulation and profound suppression of LH, FSH, and gonadal steroids. It is widely prescribed as a depot formulation for treatment of advanced prostate cancer, endometriosis, uterine fibroids, precocious puberty, and in assisted reproduction protocols. Its high potency and availability in sustained-release formulations make it one of the most commonly used GnRH agonists worldwide.
| Sequence / Structure | pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 |
| Molecular Weight | 1,311.45 g/mol |
| Purity | ≥99% |
| Appearance | White lyophilized powder |
| Storage | Store at 2-8°C, protect from light |
| Solubility | Soluble in sterile water and saline |
Kienle E, Lubelt O. (2009) — Triptorelin: a review of its use in the treatment of advanced prostate cancer. Drugs. DOI: 10.2165/00003495-200969040-00006
Schally AV. (1999) — Luteinizing hormone-releasing hormone analogs: their impact on the control of tumorigenesis. Peptides. DOI: 10.1016/S0196-9781(99)00048-1
Triptorelin is a synthetic GnRH agonist decapeptide approximately 100x more potent than native GnRH, used for controlled suppression of gonadotropin and sex steroid production.
Our wholesale Triptorelin is ≥99% purity with full analytical documentation.
Applications include GnRH receptor research, prostate cancer, endometriosis, reproductive endocrinology, and depot formulation development.
Store at 2-8°C protected from light. Use reconstituted solutions promptly.
Contact our team for MOQ and volume pricing.
Both are GnRH agonists with similar mechanisms; Triptorelin contains D-Trp6 while Leuprolide contains D-Leu6 and an ethylamide C-terminus. Clinical efficacy is comparable.
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