Urocortin (Ucn, Urocortin-1) is a 40-amino acid neuropeptide belonging to the corticotropin-releasing factor (CRF) family, sharing approximately 45% sequence homology with CRF. Unlike CRF which preferentially binds CRF-R1, Urocortin binds with high affinity to both CRF receptor subtypes (CRF-R1 and CRF-R2), with particularly strong CRF-R2 affinity. This dual receptor activation profile gives Urocortin distinct biological effects including stress-induced anorexia, anxiogenic and anxiolytic responses (dose-dependent), cardiovascular protection, gastric cytoprotection, and modulation of inflammation. Three Urocortin family members have been identified (Ucn1, Ucn2, Ucn3), each with distinct receptor selectivity profiles.
| Sequence / Structure | Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2 |
| Molecular Weight | 4,696.35 g/mol |
| Purity | ≥97% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from moisture |
| Solubility | Soluble in sterile water and dilute acetic acid |
Vaughan J, Donaldson C, Bittencourt J, et al. (1995) — Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. DOI: 10.1038/378287a0
Rademaker MT, Cameron VA, Charles CM, et al. (2005) — Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. Circulation. DOI: 10.1161/01.CIR.0000159115.55689.BE
Urocortin is a 40-amino acid CRF family neuropeptide that activates both CRF-R1 and CRF-R2, involved in stress responses, appetite, and cardiovascular regulation.
Our wholesale Urocortin is ≥97% purity with full analytical documentation.
Applications include CRF receptor pharmacology, stress biology, cardiovascular protection, appetite regulation, and GI cytoprotection.
Store at -20°C protected from moisture. Reconstituted solutions should be aliquoted and frozen.
Contact our team for MOQ and pricing.
Urocortin has stronger CRF-R2 affinity and distinct downstream effects, while CRF preferentially activates CRF-R1 and primarily mediates the classical HPA axis stress response.
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