Valorphin (VV-hemorphin-5) is a heptapeptide derived from the hemoglobin beta chain, belonging to the hemorphin family of endogenous opioid peptides. Released during enzymatic digestion of hemoglobin, Valorphin exhibits mixed opioid receptor activity with affinity for both mu and delta opioid receptors, as well as interactions with the angiotensin and bradykinin systems. Its unique multi-target pharmacological profile has made it a subject of research in pain modulation, blood pressure regulation, memory processes, and immune function. Valorphin represents an interesting class of 'cryptic' bioactive peptides — hidden within larger protein sequences and released through proteolytic processing.
| Sequence / Structure | Val-Val-Tyr-Pro-Trp-Thr-Gln |
| Molecular Weight | ~770 g/mol |
| Purity | ≥95% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, protect from moisture |
| Solubility | Soluble in sterile water and dilute acetic acid |
Karelin AA, Philippova MM, Ivanov VT. (1995) — Proteolytic degradation of hemoglobin in erythrocytes leads to biologically active peptides. Peptides. DOI: 10.1016/0196-9781(95)00095-2
Blishchenko EY, Sazonova OV, Kalinina OA, et al. (2002) — Family of hemorphins: co-relations between amino acid sequences and effects on physiological parameters. Peptides. DOI: 10.1016/S0196-9781(02)00024-2
Valorphin is a hemoglobin-derived heptapeptide with mixed opioid receptor activity, part of the hemorphin family of endogenous bioactive peptides.
Our wholesale Valorphin is ≥95% purity with HPLC verification.
Applications include opioid pharmacology, pain signaling, blood pressure regulation, and cryptic peptide biology.
Store at -20°C protected from moisture. Reconstituted solutions should be used within 7 days at 2-8°C.
Contact our team for MOQ and pricing.
Cryptic (or encrypted) peptides are bioactive sequences hidden within larger proteins, released through enzymatic processing. Valorphin is released from hemoglobin during proteolysis.
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