Ziconotide (SNX-111, marketed as Prialt) is a synthetic form of ω-conotoxin MVIIA, a 25-amino acid peptide originally isolated from the venom of the marine cone snail Conus magus. It is a potent and selective blocker of N-type voltage-gated calcium channels (Cav2.2/CACNA1B), which are critical for neurotransmitter release at primary afferent nerve terminals in the spinal cord dorsal horn. By blocking these channels, Ziconotide provides powerful analgesia through a non-opioid mechanism, making it FDA-approved (2004) for the management of severe chronic pain in patients who are intolerant or refractory to other treatments. It requires intrathecal administration due to inability to cross the blood-brain barrier.
| Sequence / Structure | CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (3 disulfide bonds) |
| Molecular Weight | 2,639.14 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at 2-8°C, protect from light |
| Solubility | Soluble in sterile water and saline |
Miljanich GP. (2004) — Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Curr Med Chem. DOI: 10.2174/0929867043455297
McGivern JG. (2007) — Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. DOI: 10.2147/nedt.2007.3.1.69
Ziconotide is a synthetic peptide from cone snail venom that blocks N-type calcium channels, providing potent non-opioid analgesia. It is FDA-approved for severe chronic pain.
Our wholesale Ziconotide is ≥98% purity with full analytical documentation.
Applications include calcium channel pharmacology, non-opioid pain research, venom peptide studies, and analgesic drug development.
Store at 2-8°C protected from light. Handle with appropriate precautions due to high pharmacological potency.
Contact our team for MOQ and volume pricing.
It represents one of the first FDA-approved drugs derived from animal venom and provides an entirely non-opioid mechanism for severe chronic pain, with no risk of respiratory depression or addiction.
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