Melanotan I (Afamelanotide) is a synthetic linear analog of alpha-melanocyte-stimulating hormone (α-MSH) with a 13-amino acid sequence. It is a potent, non-selective melanocortin receptor agonist that stimulates melanogenesis. Approved in Europe as Scenesse for erythropoietic protoporphyria (EPP), it is widely studied for photoprotection, skin pigmentation, and UV damage prevention.
| Sequence / Structure | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Molecular Weight | 1646.85 g/mol |
| Purity | ≥98% |
| Appearance | White lyophilized powder |
| Storage | Store at -20°C, reconstituted at 2-8°C |
| Solubility | Soluble in water |
Langendonk JG, Balwani M, Anderson KE, et al. (2015) — Afamelanotide for erythropoietic protoporphyria. N Engl J Med. DOI: 10.1056/NEJMoa1411481
Barnetson RS, Ooi TK, Zhuang L, et al. (2006) — Nle4-D-Phe7-alpha-melanocyte-stimulating hormone significantly increased pigmentation and decreased UV damage in fair-skinned Caucasian volunteers. J Invest Dermatol. DOI: 10.1038/sj.jid.5700436
Hadley ME, Dorr RT. (2006) — Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. DOI: 10.1016/j.peptides.2005.01.029
Melanotan I (Afamelanotide) is a synthetic linear analog of alpha-MSH that stimulates melanin production in skin cells through melanocortin receptor activation.
Melanotan I is a linear 13-amino acid peptide, while Melanotan II is a shorter cyclic 7-amino acid peptide. MT-I is more selective and has fewer side effects but is less potent.
Our wholesale Melanotan I is manufactured to ≥98% purity with complete certificates of analysis.
Yes, under the brand name Scenesse, Afamelanotide is approved in Europe for the prevention of phototoxicity in patients with erythropoietic protoporphyria.
Store lyophilized Melanotan I at -20°C. Reconstituted solutions should be kept at 2-8°C and protected from light.
Yes, we provide competitive bulk pricing with volume-based discounts. Contact us for custom quotes.
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