GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring copper complex of the tripeptide GHK. It is found in human plasma, saliva, and urine, with levels declining significantly with age. GHK-Cu has been extensively studied for its remarkable ability to stimulate collagen and elastin production, accelerate wound healing, reduce fine lines and wrinkles, improve skin firmness and elasticity, and promote hair growth. It is one of the most clinically validated cosmetic peptide ingredients, widely used in premium anti-aging skincare formulations. We supply GHK-Cu in both powder and solution forms for cosmetic manufacturers worldwide.
| Sequence | Gly-His-Lys:Cu²âº |
| Molecular Formula | C14H24CuN6O4 |
| Molecular Weight | 403.93 g/mol |
| Purity | ≥98% (HPLC) |
| Form | Lyophilized powder / Solution |
| Storage | 2-8°C |
| CAS | 49557-75-7 |
According to Pickart et al. (2015) in BioMed Research International, GHK-Cu modulates the expression of over 4,000 human genes, including those involved in tissue repair, anti-inflammation, and anti-oxidation.
Research published in the Journal of Cosmetic Dermatology (2020) demonstrated that GHK-Cu stimulates collagen I, III, and V synthesis while inhibiting metalloproteinase activity, making it a gold standard in anti-aging formulation science.
A 2017 study in Oxidative Medicine and Cellular Longevity showed that GHK-Cu's gene modulation effects may reverse age-related gene expression patterns to a more youthful profile.
Copper-binding tripeptide with clinically proven anti-aging, wound healing, and hair growth stimulation properties for cosmetic formulations.
We supply GHK-Cu (Copper Peptide) at ≥98% (HPLC) purity. Higher purity grades are available for pharmaceutical applications upon request.
Minimum order quantities for wholesale GHK-Cu (Copper Peptide) depend on the quantity and purity grade required. Contact our sales team for specific pricing and MOQ information.
GHK-Cu (Copper Peptide) should be stored at 2-8°C in a desiccated environment. Proper cold-chain shipping is maintained for all deliveries.
According to clinical studies published in the Journal of Cosmetic Dermatology, effective concentrations of GHK-Cu in topical formulations range from 0.01% to 1.0% (w/v). A 2012 double-blind study found that 0.4% GHK-Cu significantly improved skin elasticity and firmness after 12 weeks of daily application.
Research by Pickart (2008) demonstrated that GHK-Cu promotes collagen synthesis through a different mechanism than retinol, targeting the TGF-β signaling pathway while modulating 4,000+ genes. Unlike retinol, GHK-Cu does not cause photosensitivity, making it suitable for daytime formulations.
Dr. Peptides offers GHK-Cu as lyophilized powder (standard) and as pre-dissolved solution in cosmetic-grade vehicle (upon request). Available in quantities from 1g to 1kg+. We also supply GHK (without copper) for clients who prefer to complex with copper in their own formulation process.
Lyophilized GHK-Cu maintains ≥98% purity for 36+ months at -20°C. In aqueous cosmetic formulations (pH 5.0–6.5), stability studies per ICH Q1A show GHK-Cu maintains potency for 12–18 months when properly preserved and stored at room temperature.
Yes, we provide comprehensive technical documentation including recommended formulation guidelines, compatibility data with common cosmetic ingredients, stability profiles at various pH levels, and suggested incorporation methods for creams, serums, and masks. Our cosmetic application specialists are available for consultation.
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